Introduction to Carpal Tunnel Syndrome

I know lots of people love travelling, but travelling to a new time zone can result in jet lag.  Personally I did so much business travelling in my late 20's and then in my 30's I travelled for pleasure, that more recently I have been happy to stay put in England and simply pop over to Europe when I wanted some sun.  This year I am planing to go on a training course in Canada so when I saw some recent research on avoiding jet lag it caught my eye. Jet lag occurs when your circadian rhythms are slow to adjust to the new time zone and remain on their original biological schedule for several days. This results in your body telling you it is time to sleep, when it's actually the middle of the afternoon, or it makes you want to stay awake when it is late at night. Here are some tips for minimizing the occurrence of jet lag:

• Select a flight that allows early evening arrival and stay up until 10 p.m. local time. (If you must sleep during the day, take a short nap in the early afternoon, but no longer than two hours. Set an alarm to be sure not to over sleep.)
• Avoid alcohol or caffeine at least three to four hours before bedtime. Both act as "stimulants" and prevent sleep.
• Try to get outside in the sunlight whenever possible. Daylight is a powerful stimulant for regulating the biological clock. (Staying indoors worsens jet lag.)
• On the flight set the time on your watch to the local time of your destination so you can mentally start adjusting to the new time zone.
• When you arrive eat with the locals.

In part 1, I looked at the impact of sitting on your muscles,  and in part 2 I started to explore the impact on the rest of your body.  In this post I continue to explore the impact of sitting on your circulatory system including your heart. Heart Disease When sitting for prolonged periods of time, muscles burn less fat and blood flows more sluggishly, allowing fatty acids to more easily clog the heart.  In 2012 Ford & Caspersen in their research paper, Sedentary behaviour and cardiovascular disease: a review of prospective studies (International Journal of Epidemiology, Vol 41, No 5 pages 1338 - 1353) showed that the people with the most sedentary time are more than twice as likely to have cardiovascular disease than those with the least. In 2012 Zedric and Hamilton found that just a few hours sitting suppresses a gene that helps keep your cardiovascular system healthy by controlling inflammation and blood clotting. T W Zedric & M T Hamilton, 2012 Identification of hemostatic genes expressed in human and rat leg muscles and a novel gene (LPP1/PAP2a) suppressed during prolonged physical inactivity (sitting), Lipids in Health and Disease, Vol 11 see http://www.biomedcentral.com/content/pdf/1476-511X-11-137.pdf Cholesterol Sitting also means that your large postural support muscles are inactive.  When active these muscles produce a quite of beneficial molecules.  One molecule skeletal muscles produce is an enzyme called lipoprotein lipase - which you can think of as a vacuum cleaner for fats in the blood stream.  A study in rats showed that after 24 hours forced inactivity, their lipoprotein lipase acitivity was reduced by 90 - 95%, which led to a 75% drip in the ability of their muscles to remove fats from their bloodstream as will as a significant decrease in "good" (HDL) cholesterol. L Bay & Mark Hamilton, 2003, Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity, Journal of Physiology, Vol 551, No 2 pages 673 - 682.See http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2003.045591/full

At this time of year, especially living in the UK, we are very aware of the long grey days and how this can lead to a Vitamin D [...]