The relationship between vitamin D and your immune system
A growing body of scientific evidence shows that vitamin D plays a crucial role in disease prevention and maintaining optimal health. You have about 30,000 genes in your body and vitamin D affects nearly 3,000. This is in addition to all the vitamin D receptors through out your body.
Inflammation is the body’s attempt at self-protection; the aim being to remove harmful stimuli, including damaged cells, irritants, or pathogens. While inflammation is a vital part of the body’s immune response, it can also be problematic and plays a role in some chronic diseases e.g asthma, arthritis. Researchers investigated specific signalling events that vitamin D suppresses in order to inhibit inflammation. Research published in The Journal of Immunology called it the “inflammatory cascade”; low vitamin D levels failed to inhibit the cascade while adequate levels did the job. Researchers concluded that patients with chronic inflammatory diseases who are also vitamin D deficient may benefit from supplementation.
Researchers in Turkey, reported in the international Journal of Rheumatic Diseases that chronic widespread musculoskeletal pain is improved with vitamin D. Fibromyalgia sufferers and other patients with chronic widespread musculoskeletal pain were given 50,000 iu/week oral vitamin D3 for three months. Afterwards scientists discovered decreases in pain, fatigue upon awaking, lack of energy, tender points and depression. Significantly there were 30 Fibromyalgia patients at the beginning of the study and only 20 at the end!
Next week I want to look at the relationship between low vitamin D levels and common ailments.
References
Zhang Y, et al. (2012). Vitamin D Inhibits Monocyte/Macrophage Proinflammatory Cytokine Production by Targeting MAPK Phosphatase-1. The Journal of Immunology.
Yilmaz, R., Salli, A., Cingoz, H. T., Kucuksen, S. and Ugurlu, H. (2016), Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. Int J Rheum Dis.
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Can a cup of cocoa a day help you?
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Introduction to Carpal Tunnel Syndrome
Way back when I first started at Barclays, one of the first clients I treated was returning to work after being signed off with Carpal Tunnel Syndrome. Which is a common and painful disorder of the wrist, caused by pressure on the median nerve which creates numbness and tingling in the fingers. At its worse it can lead to loss of grip and permanent numbness in the fingers. Repetitive computer use thought to be one of the causes, but scientific studies have shown contradictory results. A recent review of the scientific evidence found that frequent computer or mouse use can nearly double the risk of developing the condition. Repeated tapping, scrolling and swiping on your smartphone or tablet can also lead ot carpal tunnel problems. If these sort of repeated movements are the cause then improving your posture will help. But it is also worth ruling out other possible causes such as:
- Diabetes
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More tips on how to prevent Delayed Onsite Muscle Soreness
Previously I have explained what DOMS is, and why it plagues some people and not others and given you some ideas on how to prevent it. Given DOMS can be so debilitating and demotivating I wanted to give you more tips on how to prevent DOMS. 1. Omega 3 Fatty Acids Omega 3 fatty acids, like those found in fish and flax oil, are a fantastic addition to your recovery arsenal. Your body can’t make them, so you have to eat them, they are found primarily in fish and wild game, and to a lesser degree in certain nuts and seeds. They are powerfully anti-inflammatory and pro-recovery, and are protective to connective tissue, nerve tissue, and muscle tissue. 2. Protease Enzymes A study by Innerfield in 1957 showed that protease enzyme supplementation may have anti-inflammatory effects, and others have shown them to be specifically effective at reducing DOMS. Protease enzymes include trypsin, bromelain, chymotrypsin and papain, and they help modulate the pro-inflammatory response by blocking pro-inflammatory prostaglandins and stimulating anti inflammatory processes. If you go this route, make sure you get a formula that includes that piperine. This is an ingredient extracted from pepper that increases enzyme absorption by up to 60%. You need this boost because enzymes don’t absorb that well in the gut. 3. Compression Tights Research found that marathoners who wore compression gear in the 24 hours after a race reported less soreness. The technical fabric supports muscle groups, reducing movement, which can result in less soft tissue damage. Compression can also boost circulation. However, to ensure the right level of compression, you’ll have to work out the size you need using your height and weight. 4. Foam Roller Most people are familiar with foam rollers and know that using it on sore muscles can alleivate the pain. Remember using a foam roller may be painful and shouldn't be unbearable. Personally I prefer receiving massage to foam rolling my own sore muscles. Both sports and deep tissue massage can help alleviate DOMS too. References
- Innerfield I. The anti-inflammatory effect of parenterally administered proteases. Ann N Y Acad Sci. 1957 Aug 30;68(1):167-76; discussion 176-7.
- Miller et. Al. The effects of protease supplementation on skeletal muscle function and D.O.M.S. following downhill running. Journal of Sports Sciences 22, 365-372;2004.
- Taussig SJ The mechanism of the physiological action of bromelain Medical Hypotheses 1980; 6: 99-104
- Donaho C, Rylander C Proteolytic enzymes in athletic injuries: a double blind study of a new anti-inflammatory agent Delaware Medical Journal 1962; 34: 168-170.
- Cirelli MG Clinical experience with bromelains in proteolytic enzyme therapy of inflammation and edema Medical Times 1964; 92(9): 919-922.
- Taussig SJ, Batkin S Bromelain, the enzyme complex of pineapple and its clinical application Journal of Ethnopharmacology 1988; 22: 191-203.
- Atal CK, Zutshi U, Rao PG. Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs. J Ethnopharmacol. 1981 Sep;4(2):229-32.
- Velpandian T, Jasuja R, Bhardwaj RK, Jaiswal J, Gupta SK. Piperine in food: interference in the pharmacokinetics of phenytoin. Eur J Drug Metab Pharmacokinet. 2001 Oct-Dec;26(4):241-7.
- Miller et. Al. The effects of protease supplementation on skeletal muscle function and D.O.M.S. following downhill running. Journal of Sports Sciences 22, 365-372;2004.

