What causes muscle cramps?
Unfortunately no one totally understands what causes muscle cramps. Most authorities agree that in skeletal muscles they are frequently caused by the hyper-excitability of the nerves that stimulate muscles. Rather than thinking of a single cause of muscle cramps, I find it more helpful to think in terms of risk factors.
A field study of 433 Ironman triathletes suggest that those so cramped had exercised harder than usual, had a family history of cramping and had previous tension or ligament damage. Because muscle cramps often occur due to muscle fatigue the problem may be related to nerve malfunction creates an imbalance between muscle excitation and inhibition which prevents the muscle from relaxing. (see Schwellnus et al 2004).
In summary although muscle cramps are likely to be related to overexertion there are other contribution factors.
References
Shang G, Collins M and Schwellnus M (2001). Factors associated with self-reported history of exercise associated muscle cramps in Ironman Triathletes: A case-control study, The Clinical Journal of Sports Medicine 21(3): p204-210
Schwellnus MP, Nicol J, Laubscher R et al (2004). Serum electrolyte concentrations and hydration status are not associated with exercise associated muscle cramping in distance runners, British Journal of Sports Medicine 38(4): p488-492
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More factors that contribute to muscle cramps
Previously I discussed how dehydration & lack of sodium or potassium may cause muscle cramps. I now want to explore other nutritional factors. Calcium Calcium plays an essential role in muscle contractions. Some active people report their problem with cramping disappears when they boost their calcium intake. This anecdotal evidence is disputed by scientists who state that when dietary deficiencies of of calcium occur, calcium is released from the bones to provide what the body needs for proper muscle contraction. If you are plagued by muscle cramps, it may be worth trying to increase your intake of dairy or other calcium rich foods to see if it helps. Magnesium Just as muscles need calcium to contract they need magnesium to relax. Roffe et al demonstrated that magnesium helps reduce leg cramps that occur in the middle of the night.
Reference
Roffe C1, Sills S, Crome P, Jones P (2002), Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002 May;8(5): p326-30.

